The Osiris Nexus is a raid instance in the game.
- Looking into the Eyes of Evil: Destroy fifteen of Sadralus the Tainted's Tainted Eyes before they despawn in its interlude on Standard or higher.
- An Edge Ahead: Succeed in disarming Lo'kash the Arch Blade then defeat him on Standard or higher.
- She Speaks Solemnly: Hear the final song of the Divine Priestess during the Will of the All-Fallen and defeat it on Standard or higher.
- Malus No Malice: Defeat the Council of Malus after the members form a "Osiris Paragon" on Standard or higher.
- Closing the Door: Defeat Portal Augur Volstix after witnessing at least ten different worlds on Standard or higher.
- Staggering Presence: Defeat Xeidrar the Awakened without anyone losing their Knights' Bulwark on Standard or higher.